Ariel Pablos-Méndez, a physician and epidemiologist, is Managing Director at the Rockefeller Foundation and a creative leader in global public health. As an Assistant and later Associate Professor of Clinical Medicine and Public Health at Columbia University in New York, Dr. Pablos-Méndez worked on the emergence of multi-drug resistant tuberculosis in New York City in 1991 and, in 1997, led the Global Surveillance Project on Anti-Tuberculosis Drug Resistance at the World Health Organization. In both instances, his research brought about significant and successful policy changes. His affiliation with the Rockefeller Foundation started in 1998 when Dr. Pablos-Méndez spearheaded the program “Harnessing the New Sciences” on product development for diseases of poverty through public-private partnerships. In 2000 his vision and leadership drove the creation of the Global Alliance for TB Drug Development. He also led a re-thinking of the Rockefeller Foundation’s program on AIDS and a program for the treatment of mothers with AIDS and their families (MTCT-Plus) in 2001. In 2002 Dr. Pablos-Méndez championed the creation of the international Center for the Management of IPR in Health R&D. In 2003, he managed the Joint Learning Initiative on Human Resources for Health. Dr. Pablos-Méndez served as Deputy and Interim Director of the Health Program at the Rockefeller Foundation until 2004. As Director of Knowledge Management and Sharing at WHO from 2004 to 2007, Dr. Pablos-Méndez worked to establish the principles and practice of Knowledge Management as a core competence of public health, fostering shared learning and social entrepreneurship to help bridge the know-do gap in global health. His team developed a global Knowledge Management strategy, advanced the agenda on Knowledge Translation, established the WHO Press, launched the Global Health Library, a Global Health Histories Initiative, and WHO’s e-Health unit, which produced the first global e-Health report in 2006. In 2007 Dr. Pablos-Méndez returned as Managing Director to the Rockefeller Foundation, where he is currently working on various new initiatives for global health.